Metabolism 100% in colon by enteric bacteria
Onset of action =8 to 48 hours
Lactulose solution is a synthetic disaccharide, a type of sugar that is broken down in the large intestine into mild acids that draw water into the colon, which helps soften the stools. Lactulose solution is used to treat chronic constipation.
Lactulose is also used to reduce the amount of ammonia in the blood of patients with liver disease.
Lactulose is a non-absorbable sugar used in the treatment of constipation and hepatic encephalopathy. It is used by mouth for constipation and either by mouth or in the rectum for hepatic encephalopathy. It generally begins working after eight to twelve hours but may take up to two days to improve constipation.
Lactulose is a synthetic disaccharide in solution form for oral or rectal administration. Each 15 mL of Lactulose Solution USP contains 10 g lactulose (and less than 1.6 g galactose, less than 1.2 g lactose, and 0.1 g or less of fructose). It also contains D&C Yellow No. 10, FD & C Yellow No. 6 and Purified Water.
Use of bulk-forming laxatives during pregnancy is common and has not been linked to any problems in the unborn baby. Lactulose is a type of sugar that is not digested and therefore draws water into the bowel. This softens the stools and helps them to move along the bowel.
One mild laxative, considered to be safe to take during pregnancy, is milk of magnesia. Your doctor may also recommend taking a bulk-producing agent like Metamucil. Lastly, your doctor may suggest a stool softener, which contains docusate, to reduce constipation. ... In addition, make sure you do not overuse laxatives.
Why it's used
Lactulose is used to treat constipation. It’s also used to treat a brain problem called portal-systemic encephalopathy. This problem is a complication of severe liver disease.
This drug may be used as part of a combination therapy. This means you may need to take it with other medications.
How it works
Lactulose belongs to a class of drugs called laxatives. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Lactulose is a synthetic (man-made) sugar. It breaks down in your large intestine and then draws water into the intestine. This softens your stool, which helps ease constipation.
This drug also treats high ammonia levels in the blood due to liver disease. High ammonia levels can lead to portal-systemic encephalopathy. This drug works by drawing ammonia from your blood into your large intestine. Your large intestine then removes the ammonia from your body through your stool.
How to use lactulose solution:
Use lactulose solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
•Lactulose solution may be mixed with fruit juice, water, or milk. Drink 1 or more 8-ounce glasses of liquid with each dose.
•A bowel movement should occur 24 to 48 hours after taking lactulose solution.
•If you miss a dose of lactulose solution and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.